International name (active substance): streptokinase, streptodornase
Clinical-pharmacological group: Obstetrics, gynecology → Anti-inflammatory agents for local use
Manufacturer: Farmina
Country of manufacture: Poland
Form of release: Rectal suppositories No. 6
Dispensing regimen: Group II (dispensed with prescription form N3)
Composition: Active substances:
- Streptokinase 15,000 IU
- Streptodornase 1,250 IU
Excipients:
- Liquid paraffin
- Solid fat
One suppository weighs 1.4 g.
Pharmacological Properties: Biodornase contains components with enzymatic activity: Streptokinase has a fibrinolytic effect by activating the plasminogen enzyme, which, under its influence, transitions into its active form and facilitates the resorption of thrombolytic masses.
Streptodornase – an endonuclease (deoxyribonuclease enzyme) – causes the destruction of DNA, nucleotides, and nucleosides, and breaks down necrotic and purulent masses. It does not affect the structure or function of living cells. Through the action of streptokinase and streptodornase, the concentration of phagocytes increases significantly, improving their mobility. The use of Biodornase suppositories leads to:
- Rapid lysis of leukocyte masses
- Improved blood circulation and microcirculation in the inflammatory focus
- Increased concentration of antibacterial and other medications in the inflammatory site
- Rapid relief of infiltration, swelling, and clinical symptoms
- Prevention of the development of sclerotic processes
Indications:
- Acute and chronic inflammatory diseases of the small pelvic organs:
- Inflammation of the uterine appendages
- Inflammation of the uterine mucosa
- Inflammatory diseases of the lower urinary tract
- Postoperative infiltrative damage to pelvic organs
- Acute and chronic hemorrhoids
- Perirectal abscess and fistula with extensive inflammatory infiltration
- Purulent caudal cysts
Dosage and Administration: The medication should always be used according to the doctor’s prescription. The route of administration is rectal. The suppository should be placed deeply into the rectum after defecation. The doctor determines the dosage according to the severity of the disease.
For serious and chronic conditions, the following regimen should be used:
- 1 suppository 3 times a day for 3 days
- 1 suppository twice a day for 3 days
- 1 suppository daily for 3 days
Maximum dose: 18 suppositories over 9 days
For less severe conditions: - 1 suppository twice a day for 3 days
- 1 suppository daily for 4 days
Maximum dose: 10 suppositories over a 7-day course
For mild conditions: - 1 suppository twice a day for 2 days
Maximum dose: 4 suppositories over a 2-day course
If the condition worsens or relapses, the doctor may prescribe a repeat course of treatment.
Side Effects:
- Local pain
- Local swelling
- Elevated temperature
- Bleeding at the application site
- Allergic reactions at the application site
Contraindications:
- Allergy to streptokinase, streptodornase, or any other component of the product
- New or freshly formed wounds with scabs, surgical sutures, or within 10 days after bleeding
- Combined use with anticoagulants, as it may lead to local bleeding
- Patients with blood clotting disorders
- Use with other medications containing calcium salts
Drug Interactions: The use of the product with anticoagulants is contraindicated, as it may lead to local bleeding. The doctor should be informed of any other medications the patient is taking.
Special Instructions: Consult a doctor or pharmacist before using Biodornase. The product should only be used for liquefying purulent or hemorrhagic exudates or local clots. If a dose is missed, do not take double the dose to make up for the missed one.
Pregnancy and Lactation: Consult a doctor before use if pregnant or breastfeeding.
Driving and Use of Machinery: The product does not affect the ability to drive or operate machinery.
Overdose: If the recommended dose is exceeded, immediately consult a doctor or pharmacist.
Appearance and Packaging: The cardboard box contains blister packs made from pharmaceutical foil with 6 suppositories.
Storage Conditions: Store in the original packaging, protected from light, in a place inaccessible to children, at a temperature of 2-8°C in the refrigerator. Do not freeze.
Shelf Life: As indicated on the packaging.
Pharmacy Dispensation: By prescription.
